Treatment of Experimental Portal Vein Thrombosis With Streptokinase [Tepecik Eğit Hast Derg]
Tepecik Eğit Hast Derg. 1993; 3(1): 33-36 | DOI: 10.5222/terh.1993.22534  

Treatment of Experimental Portal Vein Thrombosis With Streptokinase

Tarık Çağa1, Firdevs Gürer2, Orhan Yurtsever1, Bekir Yaşar1
1Osmangazi University, Faculty of Medicine, Department of General Surgery Eskişehir, Türkiye
2Osmangazi University, Faculty of Medicine, Department of Histology Eskişehir, Turkiye

In this experimental study. 24 rats (Mus. Norvegius Albinos) were used of which 12 were in the control group, and the other 12 in the therapeutic group. In the control group, portal vein thrombosis was created. By venous statis, and histological examinations were performed on the liver specimens, and liver function tests were also acquired for this group. In the therapeutic group, low dose streptokinase-3000 units (0.003 cc) was infused through the portal vein at which venous thrombosis had been produced experimentally. Ail the rats were sacrificed on the 7th postoperative day and histological liver examinations and biochemical studies were performed. According to the results there were no evidence of liver ischemia following the use of streptokinase.

Keywords: Liver ischemia, Plasminogene Activator


Deneysel Vena Porta Trombozunun Streptokinaz İle Tedavisi

Tarık Çağa1, Firdevs Gürer2, Orhan Yurtsever1, Bekir Yaşar1
1Osmangazi University, Faculty of Medicine, Department of General Surgery Eskişehir, Türkiye
2Osmangazi University, Faculty of Medicine, Department of Histology Eskişehir, Turkiye

Bu deneysel çalışmada, 24 sıçan (Mus. Norvegius Albunos). 12'si kontrol, diğer 12'si ise tedavi grubu olmak üzere iki ayrı gruba ayrıldı. Kontrol grubundaki sıçanlarda, vena porta staz yöntemiyle trombüs oluşturuldu ve trombüs sonrası histolojik karaciğer incelemeleri yapıldı ve karaciğer fonksiyon testlerine bakıldı. Tedavi grubunda ise, aynı yöntemle trombüs oluşturulduktan sonra, intraportal yoldan düşük doz streptokinaz 3000 ünite (0.003 cc) verildi. Tedavi grubundaki sıçanlar postoperatif 7. günde öldürülerek, postmortem histolojik ve biyokimyasal incelemeler yapıldı. Alman sonuçlara göre tedavi sonrası karaciğer iskemisine rastlanmadı.

Anahtar Kelimeler: Karaciğer iskemisi, Plazminojen Aktivatörü


Tarık Çağa, Firdevs Gürer, Orhan Yurtsever, Bekir Yaşar. Treatment of Experimental Portal Vein Thrombosis With Streptokinase. Tepecik Eğit Hast Derg. 1993; 3(1): 33-36


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