Effect of HALP Rate to Pathological Stage with Bladder Tumor Patients

Objective: In this study, to investigate the effect of preoperative hemoglobin, albumin, lymphocyte and platelet (HALP) ratio on the pathological stage in patients with bladder tumors larger than 3 cm.
Methods: In the study, 310 patients who met the inclusion criteria were evaluated who underwent transurethral resection of bladder tumors operation for the first time due to bladder tumor between 2010 and 2020 and whose data were fully collected were evaluated. The patients were divided into two groups as muscle invasive (MIBC) and non-muscle invasive bladder tumor (NMIBC) according to the pathology report. The difference between HALP values and ratios was evaluated for both groups.
Results: In the study, 310 patients included in the study with complete data, 227 (73.2%) had NMIBC and 83 (26.8%) had MIBC pathology results. Of the NMIBC patients, 157 (69%) had high-grade papillary urethelial carcinoma and 70 (31%) had low-grade papillary urethelial carcinoma. The mean HALP value for NMIBC is 28.36±2.83, the mean HALP value for MIBC is 21.45±3.14. According to the univariate analysis, it was concluded that high stage was associated with hypoalbuminemia, anemia and low HALP.
Conclusion: In this study, it was concluded that calculating the HALP rate, which is cheap, easy to apply and gives rapid results, may be a significant predictor of the pathological stages of the patients and indirectly in estimating the survival of the disease.